A reader-funded review of treatments, supplements & cutting-edge wellness · Issue No. 14 · May 2026
The Glow Diary
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The Comparison Desk

GLP-1 agonists,
side by side.

Four drugs, one rubric. We pulled every Phase III trial, every post-marketing safety report, and every real-world cost we could verify.

A bright nutrition kitchen scene for GLP-1 health support.
GLP-1 / GIPA−

Tirzepatide

Mounjaro · Zepbound

Mean loss22.5%
Monthly cost$1,059
A pilates reformer stretch representing strength and lean-mass support.
GLP-1 / GIPA−

Semaglutide

Ozempic · Wegovy

Mean loss14.9%
Monthly cost$1,349
A confident post-workout walk representing everyday metabolic health.
GLP-1 / GIPB−

Liraglutide

Saxenda · Victoza

Mean loss7.6%
Monthly cost$1,440
A restorative evening yoga scene representing recovery and consistency.
GLP-1 / GIPB+

Retatrutide

(Phase III)

Mean loss24.2%
Monthly cost—
№ 02

The full rubric

14 dimensions · Open methodology

Dimension
Tirzepatide
Semaglutide
Liraglutide
Retatrutide
Receptor activity
Best-in-class
Conservative pick
Outclassed
Emerging
Mean weight loss
Best-in-class
Conservative pick
Outclassed
Emerging
Cardiovascular outcomes
Best-in-class
Conservative pick
Outclassed
Emerging
GI side effects
Best-in-class
Conservative pick
Outclassed
Emerging
FDA status
Best-in-class
Conservative pick
Outclassed
Emerging
Glow Verdict
Best-in-class
Conservative pick
Outclassed
Emerging